Baked Pesto Chicken Mac & Cheese

Featured in: Comfort Cravings

This comforting baked casserole combines tender pesto-seasoned chicken with creamy three-cheese macaroni. A blend of mozzarella, Parmesan, and sharp cheddar creates a rich sauce that coats every piece of al dente pasta. The golden panko-Parmesan topping adds satisfying crunch to the bubbling, cheesy layer beneath. Ready in under an hour, this American-Italian fusion dish serves six generously and delivers both protein and comfort in every bite.

Updated on Mon, 09 Feb 2026 20:09:35 GMT
Golden, bubbling Baked Pesto Chicken Mac & Cheese fresh from the oven with a crunchy panko topping. Save
Golden, bubbling Baked Pesto Chicken Mac & Cheese fresh from the oven with a crunchy panko topping. | sugarprairie.com

Baked Pesto Chicken Mac & Cheese is a comforting casserole that bridges the gap between classic American soul food and the aromatic flavors of Italy. This hearty dish combines tender chicken pieces tossed in vibrant basil pesto with a velvety three-cheese sauce, all baked to perfection under a crisp, golden crust. It is a sophisticated yet simple meal that is perfect for busy weeknights or cozy family gatherings.

Golden, bubbling Baked Pesto Chicken Mac & Cheese fresh from the oven with a crunchy panko topping. Save
Golden, bubbling Baked Pesto Chicken Mac & Cheese fresh from the oven with a crunchy panko topping. | sugarprairie.com

The secret to this recipe lies in the multi-layered cheese sauce, which uses a blend of mozzarella for meltability, cheddar for sharpness, and Parmesan for a deep, savory finish. When these elements meld with the basil pesto, every bite of macaroni is infused with a rich and aromatic taste that elevates the standard mac and cheese experience.

Ingredients

  • Pasta: 400 g (14 oz) elbow macaroni
  • Chicken: 500 g (1.1 lb) boneless, skinless chicken breast (cut into bite-sized pieces), 2 tbsp olive oil, 1/2 tsp salt, 1/4 tsp black pepper, 1/2 tsp dried Italian herbs
  • Pesto: 100 g (1/2 cup) basil pesto (store-bought or homemade)
  • Sauce: 3 tbsp unsalted butter, 3 tbsp all-purpose flour, 700 ml (3 cups) whole milk, 150 g (1 1/2 cups) shredded mozzarella cheese, 100 g (1 cup) shredded Parmesan cheese, 100 g (1 cup) shredded sharp cheddar cheese, 1/2 tsp garlic powder, salt and pepper to taste
  • Topping: 40 g (1/2 cup) panko breadcrumbs, 30 g (1/4 cup) grated Parmesan cheese, 1 tbsp olive oil
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Instructions

Step 1
Preheat oven to 200°C (400°F). Grease a large baking dish (about 23x33 cm/9x13 in).
Step 2
Bring a large pot of salted water to a boil. Cook macaroni until al dente, drain, and set aside.
Step 3
While pasta cooks, heat 2 tbsp olive oil in a skillet over medium heat. Add chicken, season with salt, pepper, and Italian herbs. Cook until golden and cooked through, about 6–8 minutes. Remove from heat and toss with basil pesto.
Step 4
In a large saucepan, melt butter over medium heat. Whisk in flour and cook for 1 minute. Gradually whisk in milk, stirring constantly until thickened (about 4–5 minutes).
Step 5
Remove from heat and stir in mozzarella, Parmesan, cheddar, and garlic powder. Season with salt and pepper.
Step 6
Combine cooked macaroni, cheese sauce, and pesto chicken in a large bowl. Mix gently to coat.
Step 7
Spoon mixture into prepared baking dish.
Step 8
In a small bowl, combine panko, Parmesan, and olive oil. Sprinkle evenly over casserole.
Step 9
Bake for 20–25 minutes until bubbling and golden brown on top.
Step 10
Let rest 5 minutes before serving.

Zusatztipps für die Zubereitung

For extra color and nutrition, try adding sautéed spinach or sun-dried tomatoes to the pasta mixture before baking. If you are in a hurry, you can substitute the chicken breasts with a pre-cooked rotisserie chicken to save on preparation time.

Varianten und Anpassungen

You can easily customize the flavor of the cheese sauce by experimenting with different varieties. Try using smoked gouda or fontina for a unique and creamy twist that pairs beautifully with the basil pesto.

Serviervorschläge

This rich and decadent dish pairs perfectly with a crisp green salad to provide a refreshing contrast. For an adult dinner setting, consider serving it alongside a chilled glass of Sauvignon Blanc.

Spoonful of creamy Baked Pesto Chicken Mac & Cheese revealing tender chicken and vibrant green pesto swirls. Save
Spoonful of creamy Baked Pesto Chicken Mac & Cheese revealing tender chicken and vibrant green pesto swirls. | sugarprairie.com

Whether you are hosting a festive family gathering or simply looking for an elevated weeknight dinner, this Baked Pesto Chicken Mac & Cheese is a guaranteed winner. Serve it warm and enjoy the perfect fusion of creamy cheese, juicy chicken, and aromatic basil.

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Kitchen Help

Can I make this ahead of time?

Yes, assemble the entire casserole up to 24 hours ahead, cover tightly, and refrigerate. Add 10-15 minutes to baking time if baking cold from the refrigerator.

What other cheeses work well?

Fontina, Gruyère, or smoked Gouda add delicious depth. The current blend offers optimal melt and flavor balance, but feel free to experiment with your favorites.

Can I freeze leftovers?

Portion leftovers into airtight containers and freeze for up to 3 months. Thaw overnight in the refrigerator and reheat at 180°C (350°F) until warmed through.

How do I know when it's done baking?

The casserole is ready when cheese bubbles around the edges and the topping turns golden brown. This typically takes 20-25 minutes in a 200°C (400°F) oven.

Can I use different pasta shapes?

Elbow macaroni holds sauce beautifully, but shells, cavatappi, or penne work well too. Choose shapes with nooks and crannies to capture the cheesy pesto sauce.

Is homemade pesto better than store-bought?

Homemade pesto offers fresh basil brightness, but quality store-bought versions work perfectly. Look for brands with minimal ingredients and authentic basil flavor.

Baked Pesto Chicken Mac & Cheese

Creamy three-cheese macaroni with tender pesto chicken and crispy golden topping

Setup duration
20 min
Heat duration
35 min
Complete duration
55 min
Created by Molly Evans

Classification Comfort Cravings

Complexity Medium

Heritage American-Italian

Output 6 Portions

Nutrition guidelines None specified

Components

Pasta

01 14 ounces elbow macaroni

Chicken

01 1.1 pounds boneless, skinless chicken breast, cut into bite-sized pieces
02 2 tablespoons olive oil
03 1/2 teaspoon salt
04 1/4 teaspoon black pepper
05 1/2 teaspoon dried Italian herbs

Pesto

01 1/2 cup basil pesto, store-bought or homemade

Sauce

01 3 tablespoons unsalted butter
02 3 tablespoons all-purpose flour
03 3 cups whole milk
04 1.5 cups shredded mozzarella cheese
05 1 cup shredded Parmesan cheese
06 1 cup shredded sharp cheddar cheese
07 1/2 teaspoon garlic powder
08 Salt and black pepper to taste

Topping

01 1/2 cup panko breadcrumbs
02 1/4 cup grated Parmesan cheese
03 1 tablespoon olive oil

Method steps

Phase 01

Prepare baking vessel: Preheat oven to 400°F. Grease a 9x13 inch baking dish with butter or cooking spray.

Phase 02

Cook pasta: Bring a large pot of salted water to a rolling boil. Cook elbow macaroni until al dente according to package directions, then drain and set aside.

Phase 03

Cook chicken with pesto: While pasta cooks, heat 2 tablespoons olive oil in a skillet over medium heat. Add chicken pieces, season with salt, pepper, and Italian herbs. Cook for 6 to 8 minutes until golden and cooked through. Remove from heat and toss with basil pesto until evenly coated.

Phase 04

Create cheese sauce: In a large saucepan, melt butter over medium heat. Whisk in flour and cook for 1 minute, stirring constantly. Gradually whisk in milk while stirring continuously until sauce thickens, approximately 4 to 5 minutes.

Phase 05

Incorporate cheeses: Remove saucepan from heat. Stir in mozzarella, Parmesan, cheddar, and garlic powder. Season with salt and pepper to taste.

Phase 06

Combine ingredients: In a large mixing bowl, combine cooked macaroni, cheese sauce, and pesto chicken. Mix gently with a spatula until all ingredients are evenly coated.

Phase 07

Transfer to baking dish: Spoon the macaroni and cheese mixture into the prepared 9x13 inch baking dish, spreading evenly.

Phase 08

Prepare breadcrumb topping: In a small bowl, combine panko breadcrumbs, grated Parmesan cheese, and 1 tablespoon olive oil. Mix until breadcrumbs are evenly moistened. Sprinkle topping mixture evenly over casserole surface.

Phase 09

Bake casserole: Place baking dish in preheated 400°F oven and bake for 20 to 25 minutes until mixture is bubbling around edges and top is golden brown.

Phase 10

Rest before serving: Remove from oven and allow casserole to rest at room temperature for 5 minutes before serving.

Kitchen tools needed

  • Large pot for cooking pasta
  • 12-inch skillet for cooking chicken
  • Large saucepan for preparing cheese sauce
  • Mixing bowls for combining ingredients
  • Whisk for smoothing sauce and incorporating milk
  • 9x13 inch baking dish
  • Measuring cups and spoons for accurate ingredient portioning
  • Spatula or large spoon for gentle mixing

Dietary concerns

Review ingredients carefully for potential allergens and seek professional medical guidance if uncertain.
  • Contains gluten from pasta, all-purpose flour, and panko breadcrumbs
  • Contains dairy including whole milk, butter, and three varieties of cheese
  • Potential tree nut presence in store-bought basil pesto due to pine nuts
  • Verify all packaged ingredients for potential cross-contamination and undeclared allergens before preparation

Dietary breakdown (per portion)

Values shown are estimates only - consult healthcare providers for specific advice.
  • Energy: 620
  • Fats: 30 g
  • Carbohydrates: 52 g
  • Proteins: 36 g